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M u l t i p l e   S c l e r o s i s  ( M S )

W e b   P a g e

    MS Index          
    What is MS?
      Muscle symptoms
      Bowel And Bladder symptoms
      Eye symptoms
      Numbness, tingling, or pain
      Other brain and nerve symptoms
      Sexual symptoms
      Speech and swallowing symptoms
    Exams and Tests
    Support Groups
    Outlook (Prognosis)
    Possible Complications
    When to Contact a Medical Professional
MS; Demyelinating disease
Last reviewed: September 25, 2013
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What is MS?
  Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord (central nervous system).     ms 1
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Multiple sclerosis (MS) affects women more than men. The disorder is most commonly diagnosed between ages 20 and 40, but can be seen at any age.

MS is caused by damage to the myelin sheath, the protective covering that surrounds nerve cells. When this nerve covering is damaged, nerve signals slow down or stop.

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The nerve damage is caused by inflammation. Inflammation occurs when the body's own immune cells attack the nervous system. This can occur along any area of the brain, optic nerve, and spinal cord.

It is unknown what exactly causes this to happen. The most common thought is that a virus or gene defect, or both, are to blame. Environmental factors may play a role.

You are slightly more likely to get this condition if you have a family history of MS or live in an part of the world where MS is more common.

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Symptoms vary, because the location and severity of each attack can be different. Attacks can last for days, weeks, or months. Attacks are followed by periods of reduced or no symptoms (remissions). Fever, hot baths, sun exposure, and stress can trigger or worsen attacks.

It is common for the disease to return (relapse). However, the disease may continue to get worse without periods of remission.

Nerves in any part of the brain or spinal cord may be damaged. Because of this, MS symptoms can appear in many parts of the body.

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Muscle symptoms
  • Loss of balance
  • Numbness or abnormal sensation in any area
  • Problems moving arms or legs
  • Problems walking
  • Problems with coordination and making small movements
  • Tremor in one or more arms or legs
  • Weakness in one or more arms or legs
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Bowel and bladder symptoms:
Eye symptoms
Numbness, tingling, or pain:
Other brain and nerve symptoms:
  • Decreased attention span, poor judgment, and memory loss
  • Difficulty reasoning and solving problems
  • Depression or feelings of sadness
  • Dizziness and balance problems
Sexual symptoms:
Speech and swallowing symptoms:
  • Slurred or difficult-to-understand speech
  • Trouble chewing and swallowing
Fatigue is a common and bothersome symptom as MS progresses. It is often worse in the late afternoon.
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Exams and Tests

Symptoms of MS may be mimic those of many other nervous system problems. MS is diagnosed by ruling out other conditions.

People who have a form of MS called relapsing-remitting may have a history of at least two attacks, separated by a period of reduced or no symptoms.

The doctor may suspect MS if there are decreases in the function of two different parts of the central nervous system (such as abnormal reflexes) at two different times.

An exam of the nervous system may show reduced nerve function in one area of the body. Or it may be spread over many parts of the body.

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  This may include:
  • Abnormal nerve reflexes
  • Decreased ability to move a part of the body
  • Decreased or abnormal sensation
  • Other loss of nervous system functions
  An eye examination may show:

Tests to diagnose multiple sclerosis include:

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There is no known cure for multiple sclerosis at this time. But, there are treatments that may slow the disease. The goal of treatment is to control symptoms and help you maintain a normal quality of life.

Medicines are often taken long-term. These include:

  • Medicines to slow the disease
  • Steroids may be used to decrease the severity of attacks
  • Medicines to control symptoms: muscle spasms, urinary problems, fatigue or mood problems
The following may also be helpful for people with MS:
  • Physical therapy, speech therapy, occupational therapy, and support groups
  • Assistive devices, such as wheelchairs, bed lifts, shower chairs, walkers, and wall bars
  • A planned exercise program early in the course of the disorder
  • A healthy lifestyle, with good nutrition and enough rest and relaxation
  • Avoiding fatigue, stress, temperature extremes, and illness
  • Making changes around the home to prevent falls
  • Changes in what you eat or drink if there are swallowing problems
  • Social workers or other counseling services help to cope with the disorder and get assistance
  • Vitamin D or other supplements (talk to your doctor first) 
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Support Groups
  Living with MS may be a challenge. You can ease the stress of illness by joining an MS support group. Sharing with others who have common experiences and problems can help you not feel alone.
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Outlook (Prognosis)

Outcome varies, and is hard to predict. Although the disorder is chronic and incurable, life expectancy can be normal or almost normal. Most people with MS are active and function at work with little disability.

The following typically have the best outlook:

  • Females
  • People who were young (less than 30 years) when the disease started
  • People with infrequent attacks
  • People with a relapsing-remitting pattern
  • People who have limited disease on imaging studies

The amount of disability and discomfort depends on:

  • How often and severe the attacks are
  • The part of the central nervous system that is affected by each attack

Most people return to normal or near-normal function between attacks. Slowly, there is greater loss of function with less improvement between attacks.

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Possible Complications
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When to Contact a Medical Professional

Call your health care provider if:

  • You develop any symptoms of MS
  • Symptoms get worse, even with treatment
  • The condition worsens to the point when home care is no longer possible
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  1. Houtchens MK, Lublin FD, Miller AE, Khoury SJ. Multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system. In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley’s Neurology in Clinical Practice. 6th ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 54.
  2. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292–302 [PMC free article] [PubMed]
  3. Rubin S. Management of multiple sclerosis: an overview. Disease-a-Month. 2013;59:253–260. [PubMed]
Review Date: 9/25/2013.

Reviewed by: Joseph V. Campellone, MD, Department of Neurology, Cooper University Hospital, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.

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